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Sensory Nerve Transfers and Direct Neurotization: The New Frontier in Peripheral Nerve Surgery

International Microsurgery Journal. 2022;6(2):2
DOI: 10.24983/scitemed.imj.2022.00167
Article Type: Review Article


The field of peripheral nerve surgery has experienced significant growth over the past few years as a result of the development of more effective treatment strategies such as direct nerve coaptation or complex nerve transfers. The majority of reconstructive procedures place a high priority on restoring motor function, however sensory restoration is commonly neglected during these operations. The loss of protective sensation increases the risk of developing injuries to the body, such as corneal ulcers, pressure sores, and hand injuries on the ulnar edge. In addition, the increased risk of developing neuropathic pain or depression adversely impacts the quality of life of patients. Researchers and clinical centers have shown interest in sensory nerve reconstruction in a variety of anatomical locations. The purpose of the study is to provide a comprehensive review of the various options available for nerve transfers and direct neurotization in various parts of the body.


  • Microsurgery; nerve transfer; peripheral nerve injuries; reconstructive surgical procedures; sensation disorders


The clinical manifestations and consequences of peripheral nerve injuries have been well documented since ancient times. Nevertheless, the concepts of axonal repair and nerve reconstruction were not developed until the 20th century. The primary purpose of peripheral nerve surgery is to restore motor function, with sensory function being a secondary goal [1].

The loss of protective sensation increases the likelihood of injuries to the body, such as corneal ulcers, pressure wounds, or damage to the ulnar border of the hand. There is also a possibility that sensory loss may lead to autonomic dysfunctions, such as dry skin, a lack of sweating, and even impaired wound healing [2]. There is evidence that neuropathic pain and depression associated with sensory loss may have a negative effect on a patient's quality of life [3,4]. Due to the importance of regaining sensory function, the study aims to provide a comprehensive literature review of techniques developed for restoring sensory function in various parts of the body.

Reconstructive Strategies

Over the past decade, advances in surgical techniques have enabled a wide range of strategies to be employed to restore peripheral sensory function. Among the various methods of nerve reconstruction, primary nerve repair is considered the gold standard. When there is a long gap between nerves, surgical interventions such as nerve grafting, nerve transfers, or direct neurotization may be employed [5].

Through nerve grafting and nerve transfers, sensory function is restored by stimulating the growth of axons into a native recipient nerve. End-to-end nerve repairs are the most common type of nerve repair, but end-to-side repairs allow minimal sensation loss at the donor site, which leads to collateral sprouting in sensory nerves without an epineurial window [5,6].

If nerve endings cannot be repaired, direct neurotization may be the last option. The technique involves the connection of nerve fascicles to a target organ such as the cornea or skin. While the exact mechanism of action is unknown, it may also restore sensation and trophism [7].

In contrast to motor reconstruction, sensory reconstruction appears not to be time-sensitive, and there is no consensus regarding a maximum timeframe [6]. The following sections provide an overview of reconstructive procedures performed on the face, the breast, the upper extremities, and the lower body. Table 1 summarizes various nerve options that can be utilized in reconstructive surgery, depending on the area of the body being treated.


Facial Region

Trigeminal Sensory Neuropathy
The trigeminal nerve transmits sensory information from the head and neck through its ophthalmic (V1), maxillary (V2), and mandibular (V3) divisions. There are several etiologies that may result in changes in facial sensation, such as fractures, intracranial tumors, and iatrogenic injuries [8]. With trigeminal anesthesia, there is a risk of injury to the soft tissues of the face [9]. Injuries commonly observed during trigeminal anesthesia are biting of the lip, cheek, and tongue on the affected side, which may occur without nociceptive feedback. Occasionally, trigeminal anesthesia can result in corneal ulceration, which can eventually lead to blindness in some cases. Trigeminal trophic syndrome can also develop in a subset of patients following trigeminal anesthesia [9].

Tactile sensation can be restored in the maxillary (V2) and mandibular (V3) territories by transferring axons from the contralateral infraorbital and mental nerves either directly or by means of cross-face grafts. Several studies have demonstrated that facial sensation can be restored within a few months following surgery. Kaban and Upton report the case of a female patient who gradually regained sensation of the left mental nerve distribution as well as light touch and protective sensations one year after surgery [10]. Koshima et al. reported two cases of trigeminal nerve II palsy that were repaired by contralateral trigeminal nerve transfer without the use of any nerve graft [11]. The affected upper labial sensory recovery was 1.65 to 2.44 (Semmes-Weinstein values) and 15 to 30 mm (moving 2-point discriminations) in the 12 to 18 months following surgery. Catapano et al. published a case series in which the return of protective sensation was obtained after 5 months of surgery [12]. Moreover, tactile sensation in the lower lips was restored after 12 months of treatment. A case reported by Mucci and Dellon described a successful transfer of the supraclavicular nerve to the mental nerve, which resulted in the return of protective sensation and tactile sensation to the lower lip [13].

Neurotrophic Keratopathy
It is well known that neurotrophic keratopathy greatly increases the risk of corneal ulcers, scarring, and loss of vision. A potentially curative surgical procedure, corneal neurotization, has recently been introduced as a means of preventing complications associated with neurotrophic keratopathy for patients. It has been shown that this procedure can effectively restore corneal sensitivity and reverse corneal changes [14].

As early as 2009, Terzis et al. reported direct corneal neurotization through the transfer of contralateral supraorbital and supratrochlear nerves to the sclerocorneal limbus (direct corneal neurotization, Figure 1) [14]. The technique was later simplified by interposing nerve grafts between the contralateral supratrochlear nerve and the cornea (indirect corneal neurotization) [15]. Both direct and indirect approaches to corneal neurotization result in comparable improvements in corneal sensitivity, trophism, and sub-basal nerve restoration after surgery [16].


Figure 1. The case illustrates a 16-year-old male with neurotrophic keratopathy following the removal of an intracranial tumor. (A) A photograph taken during surgery demonstrates the opacity of the cornea and the nerve graft ends at the sclerocorneal limbus. (B) The postoperative photograph shows that the opacity has resolved one year following the procedure.


Lingual Nerve Neuropathy
The lingual nerve is particularly susceptible to iatrogenic damage during the extraction of the third molar due to the proximity of the nerves in the area, resulting in pain, altered sensations, and even numbness in the anterior third of the tongue [17]. It has been demonstrated that indirect graft nerve repair, whether using an autograft or an allograft, is associated with improved subjective and objective nerve outcomes when compared to direct nerve repair [17]. However, in special circumstances such as large oncological resections where the ipsilateral trunk is not available, bridging from the contralateral lingual nerve may be necessary [2].


The technique of oncological breast surgery has evolved towards less invasive techniques with improved aesthetics. Nevertheless, diminished breast sensation after a mastectomy remains one of the most common complaints. There is a possibility that spontaneous sensory recovery may occur, but the timing of recovery is unpredictable. According to the literature, the rate of recovery may vary between 0% and 47% [18-20].

Harvesting a sensory cutaneous nerve from the transferred flap is an option for providing sensation following autologous breast reconstruction. A variety of different nerves are commonly used as donor nerves. The 10th and 12th intercostal nerves are commonly used as donor nerves for abdominal flaps, the thoracodorsal nerve for the latissimus dorsi flap, and the lateral femoral cutaneous nerve for the anterolateral thigh flap. These nerves are usually coapted to the 4th to 7th intercostal nerves at the recipient site [21,22].

There is evidence from two systematic reviews that the sensory function of neurotized flaps may recover more quickly than that of non-neurotized flaps, which may result in improved quality of life for patients [18,23]. Research has shown that abdominal-based flaps and latissimus dorsi flaps provide the most favorable results. While neurotization has produced positive results, its effectiveness is still subject to debate due to its added operating time, donor site morbidity, and cost [23].

Recent studies have suggested that it may be possible to direct neurotize the nipple-areola complex by using the 4th intercostal nerve after nipple-preserving mastectomy. There have been several promising early reports on the recovery of sensation 10 to 15 months after the procedure [24-26].

Upper Extremities

Hand and digital nerve reconstruction are commonly performed procedures to restore fingertip sensation, which is essential for fine motor tasks [27]. In most cases, direct nerve repair or nerve graft interposition results in successful results; however, distal nerve transfers are required in patients with large nerve gaps or proximal injuries [28-30].

Median Nerve Deficit
The median nerve deficit results in loss of sensation along the volar aspects of the thumb, index, long, and radial borders of the ring fingers. In order to restore sensory function to the first web space, terminal branches of the ulnar nerve (such as the common digital nerve) can be transferred to the fourth web space or the dorsal cutaneous branch to the first web space nerves in a direct end-to-end manner. It has been reported that the common digital nerves of the second and third web spaces can be transferred end-to-side to the ulnar digital nerve of the small finger to restore protective sensation in less critical distributions [30].

Ulnar Nerve Deficit
The ulnar nerve injury results in diminished sensation in the fourth web space and on the ulnar side of the small finger, which are essential for grasping and protective sensation. Reconstruction can be accomplished by performing an end-to-end transfer from the median nerve fascicle to the third web space and to the ulnar sensory fascicle. In this area, alternative donors may include the palmar cutaneous nerve branch or even the median nerve proper [31]. When both the median and ulnar nerves are injured, it may be beneficial to transfer the superficial branch of the radial nerve to both targets to restore protective sensation to their respective territories [32,33].

Radial Nerve Deficit
The dorsum of the hand is not considered to be a critical surface, however, some strategies have been developed to restore sensory function in patients with radial nerve injuries, such as a direct end-to-side transfer of the radial nerve to the median nerve, or a lateral antebrachial cutaneous nerve transfer to the radial nerve [28].

Lower Body

Sensate reconstruction of the lower body is of significant benefit to patients who have suffered spinal cord injuries or peripheral nerve damage in their lower limbs. The loss of protective sensation can result in repeated trauma, chronic non-healing ulcers, infections, malnutrition, and even amputation of the limbs if it is not treated in time [34].

Transfer of Sensory Branches from the Peroneal Nerve
Several nerve transfers have been described for the legs, although these are far less common than those described for the upper extremities. It was initially reported by Gordon and Buncke [35] that nerve transfers from the sensory branches of the peroneal nerve to either the tibial nerve or the sural nerve can restore protective sensation to the plantar region [35-37].

Transfer of the Saphenous Branch of the Femoral Nerve
In cases where there is no access to the peroneal nerves, such as when proximal sciatic nerve injuries have occurred, it may be possible to transfer the saphenous branch of the femoral nerve to the distal tibial nerve or sural nerve. The method has been shown to be capable of recovering sensitivity up to useful discriminatory sensitivity in accordance with the British Medical Research Council classification in two case studies [38,39].

Pressure Ulcers
The incidence of pressure ulcers among patients with spinal cord injuries ranges from 10 to 20% [34]. Typical management strategies include continuous mobilization of the patient as well as regional flap rotation to eliminate dead spaces. Unfortunately, insensate flaps may also result in ulceration over time.

Although several motor nerve transfers have been described for tetraplegic patients, only two types of sensory nerve transfers have been reported to prevent paraplegic pressure ulcers in patients by improving sacral sensation or providing sensory feedback to pressure-bearing areas. According to Mackinnon et al. [40], the medial antebrachial cutaneous nerve can be transferred to the lateral femoral cutaneous nerve. In one study, Viterbo and Ripari performed nerve transfers from the intercostal nerve to the sciatic nerve [41].

In the 1970's, Dibbell [42] and Daniel et al. [43] described a technique for mobilizing sensate tissue over an anesthetic area using long flaps innervated by the intercostal nerves. It should be noted that in subsequent studies several regional sensate flaps were described, with the ideal flap often depending on the level of injury. As one example, the tensor fascial lata flap can be performed if the lesion is below the level of the L3/4 [44], and the sensate pedicled anterolateral thigh flap can be performed if the lesion is below the level of the L2 [45].

Anterolateral Thigh Flaps
With the advancement of microsurgery, it is now possible to create sensate free flaps using sensory nerves that are available in the lower limbs or above the level of spinal cord damage [46]. Anterolateral thigh flaps that are neurotized by the lateral femoral cutaneous nerve have been the most extensively studied flaps, with reported superior aesthetic results and the possibility of early rehabilitation and function. In the study, 100% of the subjects had regained touch and nociception, and 85% had regained thermal sensitivity (Figure 2) [47]. Comparison between neurotized and non-neurotized flaps found that 76% of patients had sensory recovery after 3 months in the neurotized group, compared to 20% in the non-neurotized group [48].


Figure 2. This case illustrates the neurotized anterolateral thigh flap performed on a 50-year-old male with third degree burns on his lower leg and foot. (A) This intraoperative photography illustrates the end-to-side neurorrhaphy from the femoral cutaneous nerve (white arrow) to the superficial peroneal nerve (black arrow). (B) A photograph taken prior to surgery. (C) The postoperative outcome.


Erectile dysfunction is a common complication after a radical prostatectomy. Currently, the majority of management strategies are based on pharmacological interventions. In some cases, surgeons have attempted direct repair or grafting of the pudendal nerve, but the results have been unsatisfactory [49,50]. Souza et al. reported in 2017 that the femoral nerve may be used to neurotize the dorsal nerve of the penis and the corpus cavernosum [50]. Thirteen months after reinnervation surgery, 60% of patients were able to achieve full penetration. According to their findings, penile reinnervation surgery proved to be a viable and effective method for treating erectile dysfunction following radical prostatectomy.

In patients with low spinal injuries and normal inguinal sensations, it is possible to improve sensation, sexuality, and quality of life through the TOMAX (TO MAX-imize sensation, sexuality, and quality of life) procedure, which consists of neurotizing the dorsal nerve of the penis with the ilioinguinal nerve. According to its proponents, 24 of 30 patients (80%) reported a return to glans sensation after receiving the TOMAX procedure [51].

There is evidence that phalloplasty may be complemented by flap neurotization. This can either be done on the dorsal nerve of the penis in males, or on the inguinal nerve in transgender individuals. A complete return to sensation was observed in both groups [52,53].

In recent studies, it has been suggested that females who have suffered genital mutilation may benefit from the reconstruction of the sensate clitoris through the use of neurotized flaps attached to the pudendal nerve [54] and sensate labial flaps [55], although the results from such procedures are currently limited.


Although many advances have been made in the field of sensory nerve transfers and direct neurotization, it appears that specialized rehabilitation protocols capable of facilitating the reconstruction of sensory functions will be the direction of this field in the future. A second concern is the difficulty of objectively evaluating postoperative outcomes due to the wide range of parameters that can be measured, including tactile sensation, temperature, vibration, and erogenous sensation.


Sensory nerve reconstruction is one of the most fascinating, innovative, and pioneering chapters in peripheral nerve reconstruction. Numerous surgical techniques have been described in the literature; however, evidence-based results are lacking, as most of the reports are retrospective case studies, which are likely to be biased. A surgeon should be aware, however, that sensory restoration is an achievable goal during peripheral nerve reconstruction and should be explored as a potential means of improving the patient's quality of life.


  1. Farnebo S, Thorfinn J, Dahlin LB. Peripheral nerve injuries of the upper extremity. In: Hand and Upper Extremity (A volume in the Plastic Surgery 6-Volume Set). 4th ed. Edited by Neligan PC, Chang J. Elsevier Health Sciences;2018:714-739.
  2. Chang TNJ. Beyond frontier of peripheral nerve surgery - sensory, autonomic, and robotic approach. The 5th Congress of Asian Pacific Federation of Societies for Reconstructive Microsurgery (APFSRM). Tsukuba, Ibaraki, Japan, December 1-3, 2021.
  3. Wunderlich RP, Armstrong DG, Husain K, Lavery LA. Defining loss of protective sensation in the diabetic foot. Adv Wound Care 1998;11(3):123-128. [View Article]
  4. Bertelli JA, Ghizoni MF. Nerve transfer for sensory reconstruction of C8-T1 dermatomes in tetraplegia. Microsurgery 2016;36(8):637-641. [View Article]
  5. Ray WZ, Mackinnon SE. Management of nerve gaps: Autografts, allografts, nerve transfers, and end-to-side neurorrhaphy. Exp Neurol 2010;223(1):77-85. [View Article]
  6. Boyd KU, Fox IK. Nerve repair and grafting. In: Nerve Surgery. Vol 1, 1st ed. Edited by Mackinnon SE. New York: Thieme; 2015:75-100.
  7. Horen SR, Hamidian Jahromi A, Konofaos P. Direct neurotization: Past, present, and future considerations. Ann Plast Surg 2022;88(3):308-312. [View Article]
  8. Liu X, Daugherty R, Konofaos P. Sensory restoration of the facial region. Ann Plast Surg 2019;82(6):700-707. [View Article]
  9. Jowett N, Pineda R, 2nd. Corneal and facial sensory neurotization in trigeminal anesthesia. Facial Plast Surg Clin North Am 2021;29(3):459-470. [View Article]
  10. Kaban LB, Upton J. Cross mental nerve graft for restoration of lip sensation after inferior alveolar nerve damage: Report of case. J Oral Maxillofac Surg 1986;44(8):649-651. [View Article]
  11. Koshima I, Narushima M, Mihara M, Uchida G, Nakagawa M. Cross-face nerve transfer for established trigeminal branch II palsy. Ann Plast Surg 2009;63(6):621-623. [View Article]
  12. Catapano J, Scholl D, Ho E, Zuker RM, Borschel GH. Restoration of trigeminal cutaneous sensation with cross-face sural nerve grafts: A novel approach to facial sensory rehabilitation. Plast Reconstr Surg 2015;136(3):568-571. [View Article]
  13. Mucci SJ, Dellon AL. Restoration of lower-lip sensation: Neurotization of the mental nerve with the supraclavicular nerve. J Reconstr Microsurg 1997;13(3):151-155. [View Article]
  14. Terzis JK, Dryer MM, Bodner BI. Corneal neurotization: A novel solution to neurotrophic keratopathy. Plast Reconstr Surg 2009;123(1):112-120. [View Article]
  15. Elbaz U, Bains R, Zuker RM, Borschel GH, Ali A. Restoration of corneal sensation with regional nerve transfers and nerve grafts: A new approach to a difficult problem. JAMA Ophthalmol 2014;132(11):1289-1295. [View Article]
  16. Fogagnolo P, Giannaccare G, Bolognesi F, et al. Direct versus indirect corneal neurotization for the treatment of neurotrophic keratopathy: A multicenter prospective comparative study. Am J Ophthalmol 2020;220:203-214. [View Article]
  17. Miloro M, Ruckman P, 3rd, Kolokythas A. Lingual nerve repair: To graft or not to graft? J Oral Maxillofac Surg 2015;73(9):1844-1850. [View Article]
  18. Weissler JM, Koltz PF, Carney MJ, Serletti JM, Wu LC. Sifting through the evidence: A comprehensive review and analysis of neurotization in breast reconstruction. Plast Reconstr Surg 2018;141(3):550-565. [View Article]
  19. Tuinder SMH, Cornelissen AJM, Beugels J, van der Hulst R. Sifting through the evidence: A comprehensive review and analysis of neurotization in breast reconstruction. Plast Reconstr Surg 2018;142(6):974e-975e. [View Article]
  20. Stromps JP, Bozkurt A, Grieb G, Kim BS, Wiezik M, Pallua N. Spontaneous reinnervation of deep inferior epigastric perforator flaps after delayed breast reconstruction. J Reconstr Microsurg 2016;32(3):169-177. [View Article]
  21. Gatherwright J, Knackstedt R, Djohan R. Anatomic targets for breast reconstruction neurotization: Past results and future possibilities. Ann Plast Surg 2019;82(2):207-212. [View Article]
  22. Ducic I, Yoon J, Momeni A, Ahcan U. Anatomical considerations to optimize sensory recovery in breast neurotization with allograft. Plast Reconstr Surg Glob Open 2018;6(11):e1985. [View Article]
  23. Shridharani SM, Magarakis M, Stapleton SM, Basdag B, Seal SM, Rosson GD. Breast sensation after breast reconstruction: A systematic review. J Reconstr Microsurg 2010;26(5):303-310. [View Article]
  24. Rochlin DH, Brazio P, Wapnir I, Nguyen D. Immediate targeted nipple-areolar complex reinnervation: Improving outcomes in gender-affirming mastectomy. Plast Reconstr Surg Glob Open 2020;8(3):e2719. [View Article]
  25. Peled AW, Peled ZM. Nerve preservation and allografting for sensory innervation following immediate implant breast reconstruction. Plast Reconstr Surg Glob Open 2019;7(7):e2332. [View Article]
  26. Telich-Tarriba JE, Garza-Arriaga D, López-Garibay A, Navarro-Barquin D, Cardenas-Mejia A. Late sensory neurotization of the nipple-areola complex after implant-based breast reconstruction. Arch Breast Cancer 2022;9(2):247-249. [View Article]
  27. Telich-Tarriba J, Santos-Gallegos I, Cardenas-Mejia A, Arroyo-Berezowsky C. Characteristics of fingertip injuries and proposal of a treatment algorithm from a hand surgery referral center in Mexico City. Acta Chir Plast 2021;63(3):113-117. [View Article]
  28. Moore AM, Franco M, Tung TH. Motor and sensory nerve transfers in the forearm and hand. Plast Reconstr Surg 2014;134(4):721-730. [View Article]
  29. Brown JM, Mackinnon SE. Nerve transfers in the forearm and hand. Hand Clin 2008;24(4):319-340, v. [View Article]
  30. Boyd KU, Nimigan AS, Mackinnon SE. Nerve reconstruction in the hand and upper extremity. Clin Plast Surg 2011;38(4):643-660. [View Article]
  31. Davidge KM, Boyd KU. Ulnar nerve entrapment and injury. In: Nerve Surgery. Vol 1, 1st ed. Edited by Mackinnon SE. New York: Thieme; 2015:251-288.
  32. Schenck TL, Lin S, Stewart JK, et al. Sensory reanimation of the hand by transfer of the superficial branch of the radial nerve to the median and ulnar nerve. Brain Behav 2016;6(12):e00578. [View Article]
  33. Matloubi R. Transfer of sensory branches of radial nerve in hand surgery. J Hand Surg Br 1988;13(1):92-95. [View Article]
  34. Zakrasek EC, Creasey G, Crew JD. Pressure ulcers in people with spinal cord injury in developing nations. Spinal Cord 2015;53(1):7-13. [View Article]
  35. Gordon L, Buncke HJ. Restoration of sensation to the sole of the foot by nerve transfer. A case report. J Bone Joint Surg Am 1981;63(5):828-830. [View Article]
  36. Koshima I, Nanba Y, Tsutsui T, Takahashi Y. Deep peroneal nerve transfer for established plantar sensory loss. J Reconstr Microsurg 2003;19(7):451-454. [View Article]
  37. Rodriguez-Lorenzo A, Gago B, Pineda AF, Bhatti M, Audolfsson T. Superficial peroneal and sural nerve transfer to tibial nerve for restoration of plantar sensation after complex injuries of the tibial nerve: Cadaver feasibility study. J Plast Reconstr Aesthet Surg 2011;64(11):1512-1516. [View Article]
  38. Moore AM, Krauss EM, Parikh RP, Franco MJ, Tung TH. Femoral nerve transfers for restoring tibial nerve function: An anatomical study and clinical correlation: A report of 2 cases. J Neurosurg 2018;129(4):1024-1033. [View Article]
  39. Agarwal P, Shukla P, Sharma D. Saphenous nerve transfer: A new approach to restore sensation of the sole. J Plast Reconstr Aesthet Surg 2018;71(12):1704-1710. [View Article]
  40. Mackinnon SE, Dellon AL, Patterson GA, Gruss JS. Medial antebrachial cutaneous-lateral femoral cutaneous neurotization to provide sensation to pressure-bearing areas in the paraplegic patient. Ann Plast Surg 1985;14(6):541-544. [View Article]
  41. Viterbo F, Ripari WT. Nerve grafts prevent paraplegic pressure ulcers. J Reconstr Microsurg 2008;24(4):251-253. [View Article]
  42. Dibbell DG. Use of a long island flap to bring sensation to the sacral area in young paraplegics. Plast Reconstr Surg 1974;54(2):220-223. [View Article]
  43. Daniel RK, Terzis JK, Cunningham DM. Sensory skin flaps for coverage of pressure sores in paraplegic patients. A preliminary report. Plast Reconstr Surg 1976;58(3):317-328. [View Article]
  44. Krupp S, Kuhn W, Zaech GA. The use of innervated flaps for the closure of ischial pressure sores. Paraplegia 1983;21(2):119-126. [View Article]
  45. Santanelli Di Pompeo F, Longo B, Pagnoni M, Laporta R. Sensate anterolateral thigh perforator flap for ischiatic sores reconstruction in meningomyelocele patients. Microsurgery 2015;35(4):279-283. [View Article]
  46. Goldberg JA, Barwick WJ, Levin LS. Restoration of sensation in paraplegia by a sensory innervated plantar fillet free flap. Case report. Paraplegia 1995;33(2):116-119. [View Article]
  47. Torres-Ortiz Zermeno CA, Lopez Mendoza J. Aesthetic and functional outcomes of the innervated and thinned anterolateral thigh flap in reconstruction of upper limb defects. Plast Surg Int 2014;2014:489012. [View Article]
  48. Hong JP, Kim EK. Sole reconstruction using anterolateral thigh perforator free flaps. Plast Reconstr Surg 2007;119(1):186-193. [View Article]
  49. Shauly O, Gould DJ, Patel KM. Penile reinnervation surgery: A comprehensive review of the literature. Ann Plast Surg 2019;83(3):326-333. [View Article]
  50. Souza Trindade JC, Viterbo F, Petean Trindade A, Favaro WJ, Trindade-Filho JCS. Long-term follow-up of treatment of erectile dysfunction after radical prostatectomy using nerve grafts and end-to-side somatic-autonomic neurorraphy: A new technique. BJU Int 2017;119(6):948-954. [View Article]
  51. Overgoor MLE, de Jong T, Kon M. Restoring tactile and erogenous penile sensation in low-spinal-lesion patients: Procedural and technical aspects following 43 TOMAX nerve transfer procedures. Plast Reconstr Surg 2014;134(2):294e-301e. [View Article]
  52. Ma S, Cheng K, Liu Y. Sensibility following innervated free radial forearm flap for penile reconstruction. Plast Reconstr Surg 2011;127(1):235-241. [View Article]
  53. Kuenzlen L, Nasim S, van Neerven S, et al. Multimodal evaluation of functional nerve regeneration in transgender individuals after phalloplasty with a free radial forearm flap. J Sex Med 2020;17(5):1012-1024. [View Article]
  54. Oles N, Preston S, Leto Barone AA, Khan A, Coon D. Sensate total clitoris reconstruction via microneurovascular dorsal foot web space flap with pudendal nerve coaptation. Microsurgery 2021;41(8):787-791. [View Article]
  55. Wilson AM, Zaki AA. Novel clitoral reconstruction and coverage with sensate labial flaps: Potential remedy for female genital mutilation. Aesthet Surg J 2022;42(2):183-192. [View Article]

Editorial Information

Publication History

Received date: March 29, 2022
Accepted date: September 13, 2022
Published date: November 30, 2022


The authors would like to thank Dr. Tommy Nai-Jen Chang for his valuable input and for taking the time to share his insights with them. Additionally, the authors wish to acknowledge the support provided by the International Microsurgery Journal and the International Microsurgery Club.


The manuscript has not been presented at any meetings on the topic.

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This research has received no specific grant from any funding agency either in the public, commercial, or not-for-profit sectors.

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Department of Plastic and Reconstructive Surgery, Hospital Angeles Pedregal, Mexico City, Mexico
Department of Plastic and Reconstructive Surgery, Centro Medico Nacional 20 de Noviembre, ISSSTE, Mexico City, Mexico
Plastic and Reconstructive Surgery Division, Hospital General Dr. Manuel Gea Gonzalez, Mexico City, Mexico
Department of Plastic and Reconstructive Surgery, Hospital Angeles Pedregal, Mexico City, Mexico
Address: Camino a Santa Teresa 1055-1180, Heroes de Padierna, Magdalena Contreras 10700, Mexico City, Mexico

Video 1. Conversations with SciTeMed editors and expert mentors.

Table 1.jpgVarious Nerve Options for Reconstructive Surgery Depending on the Region of the Body

Figure 1.JPG
Figure 1. The case illustrates a 16-year-old male with neurotrophic keratopathy following the removal of an intracranial tumor. (A) A photograph taken during surgery demonstrates the opacity of the cornea and the nerve graft ends at the sclerocorneal limbus. (B) The postoperative photograph shows that the opacity has resolved one year following the procedure.
Figure 2.JPG
Figure 2. This case illustrates the neurotized anterolateral thigh flap performed on a 50-year-old male with third degree burns on his lower leg and foot. (A) This intraoperative photography illustrates the end-to-side neurorrhaphy from the femoral cutaneous nerve (white arrow) to the superficial peroneal nerve (black arrow). (B) A photograph taken prior to surgery. (C) The postoperative outcome.


Conversations with Expert Mentors

The corresponding author, Dr. Jose E. Telich-Tarriba, met with the editors and expert mentors of SciTeMed to maximize the impact and dissemination of the article. We were delighted to have five distinguished guests participate in this webinar, including Dr. Ronald M. Zuker, Dr. Sami Tuffaha, Dr. Peter Neligan, Dr. Hari Venkatramani, and Dr. Tommy Nai-Jen Chang. Dr. Tommy Nai-Jen Chang is the Editor-in-Chief of the International Microsurgery Journal. Dr. Ronald M. Zuker and Dr. Peter Neligan both serve as Honorary Editors-in-Chief of the International Microsurgery Journal. The webinar was moderated by Dr. Urska Cebron, a medical doctor and researcher at the HELIOS Klinikum Emil von Behring in Berlin, Germany.

Ronald M. Zuker, MD, FRCSC, FACS, FAAP, FRCSEd (Hon)

Dr. Ronald M. Zuker is one of the most prominent pioneers in the field of microsurgery. His publications include more than 100 peer-reviewed scientific papers and book chapters. A notable achievement of his career has been the publication of Principles and Practice of Pediatric Plastic Surgery (co-edited with Bruce Bauer and Mike Bentz), which is the standard text for pediatric plastic and reconstructive surgery. Dr. Zuker is best known for his work as the "Smile Doctor" since he has dedicated himself to restoring function to patients suffering from facial paralysis and Moebius syndrome. He has revolutionized the approach to the treatment of established facial paralysis through the use of free functioning muscle transfers, in which the gracilis muscle plays a critical role. The experience of Dr. Zuker in separating conjoined twins (seven) is one of the largest in the world. Through the implementation of microsurgery into the liver transplant team, Dr. Zuker has set the bar high and created unprecedented success rates following living donor liver transplants. In addition, he performed the first lower limb allotransplant in the world. There is an anatomic point named after him. In June 2014, Dr. Zuker was awarded the Canadian Society Lifetime Achievement Award for his contributions to the field of Plastic & Reconstructive Surgery.

Sami Tuffaha, MD

Dr. Sami Tuffaha is a hand surgeon with fellowship training at The Curtis National Hand Center. He is also an Assistant Professor in the Departments of Plastic Surgery, Orthopedic Surgery, and Neurosurgery at Johns Hopkins University. Dr. Tuffaha completed his residency at the Johns Hopkins/University of Maryland Plastic and Reconstructive Training Program. Following this, he completed a fellowship in Hand and Upper Extremity Surgery at the Mayo Clinic, where he focused on microsurgery and peripheral nerve surgery. Dr. Tuffaha has a special interest and expertise in treating peripheral nerve disorders. His research program integrates basic, translational, and clinical research in order to develop strategies to enhance nerve regeneration and functional recovery following peripheral nerve injury. Among these efforts is an ongoing clinical trial examining the efficacy of a therapeutic agent he developed in the lab.

Peter Neligan, MB, FACS, FRCSI, FRCSC

Dr. Peter Neligan is the Honorary Editor-in-Chief of the International Microsurgery Journal. He is a former president of the Plastic Surgery Foundation, of the American Society for Reconstructive Microsurgery, and of the North American Skull Base Society. He is also a former board member of the American Head & Neck Society. Previously, he served as a trustee of the American Society of Plastic Surgeons. Dr. Neligan has authored more than 12 books, 85 book chapters, and over 200 peer-reviewed publications. At present, he serves as Editor-in-Chief of Plastic Surgery, a six-volume textbook used throughout the world for plastic surgery training. He has been invited to over 300 universities and major societies as a visiting professor or honored guest. Besides serving on several editorial boards, he has previously served as Editor-in-Chief of the Journal of Reconstructive Microsurgery.

Hari Venkatramani, MD

With over 21 years of experience as a plastic and reconstructive surgeon, Dr. Hari Venkatramani is an expert in his field. He specializes in reconstructive surgery, including the reconstruction of major limbs and the reconstruction of the brachial plexus. He also performs microsurgery for the reconstruction of cancer and the treatment of lymphedema. Currently, he is a senior consultant at the Department of Plastic, Hand, and Reconstructive Microsurgery at the prestigious Ganga Hospital in Coimbatore, which is one of the largest trauma, plastic surgery, and orthopedic hospitals in India. Dr. Venkatramani serves as secretary of the Indian Society for Reconstructive Microsurgery as well as the Brachial Plexus Surgery Group of India. During his career, he has published 75 peer-reviewed journal articles as well as 12 book chapters.

Tommy Nai-Jen Chang, MD

Dr. Tommy Nai-Jen Chang is a board-certified plastic surgeon in Taiwan. He is an Associate Professor in the Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Microsurgery, Chang-Gung Memorial Hospital, Linkou Medical Center, Taiwan. In his current position, Dr. Chang is collaborating with Professor David Chwei-Chin Chuang in the area of peripheral nerve reconstruction for brachial plexus injuries in adults and children, facial paralysis, upper and lower extremity reconstruction, as well as decompression neuropathy, including carpal tunnel syndrome, ulnar tunnel syndrome, thoracic outlet syndrome and neurogenic tumors. A total of 80 articles have been published in the literature until the year 2022, mainly in the field of reconstructive microsurgery. Among his research interests are peripheral nerve regeneration and reconstruction, as well as the use of social media in microsurgery education. Dr. Chang founded the International Microsurgery Club in 2016; until now, this group represents the largest online microsurgery platform. Dr. Chang was appointed editor-in-chief of the International Microsurgery Journal in 2017, and in 2018, he founded the International Microsurgery Website to provide educational resources for microsurgery surgeons worldwide.